Publications: Dr. Melkani's Lab Home Page

Publications from Dr. Melkani's Lab

Villanueva JE, Livelo C, Trujillo AS, Chandran S, Woodworth B, Andrade L, Le HD, Manor U, Panda S, Melkani GC. (2019) Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. Nat Commun. 2019 Jun 20;10(1):2700.

Chaix A, Manoogian ENC, Melkani GC, Panda S. (2019) Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases. Annu Rev Nutr. 2019 Jun 10.

Chandran S, Suggs JA, Wang BJ, Han A, Bhide S, Cryderman DE, Moore SA, Bernstein SI, Wallrath LL, Melkani GC. (2019) Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling. Hum Mol Genet. 2019 Feb 1;28(3):351-371.

Kronert WA, Bell KM, Viswanathan MC, Melkani GC, Trujillo AS, Huang A, Melkani A, Cammarato A, Swank DM, Bernstein SI. (2018) Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy. Elife. 2018 Aug 13;7

Shruti Bhide, Adriana S. Trujillo, Maureen T. O'Connor, Grant H. Young, Diane E. Cryderman, Sahaana Chandran, Mastaneh Nikravesh, Lori L. Wallrath, Girish C. Melkani (2018) Increasing autophagy and blocking Nrf2 suppress laminopathy‐induced age‐dependent cardiac dysfunction and shortened lifespan. Aging Cell DOI: 10.1111/acel.12747

Melkani GC, Panda S. (2017) Time-restricted feeding for prevention and treatment of cardiometabolic disorders. J Physiol. Jun 15;595(12):3691-3700.

Melkani GC, Bhide S, Han A, Vyas J, Livelo C, Bodmer R, Bernstein SI. (2017) TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. FEBS Lett. Nov;591(21):3447-3458.

Suggs JA, Melkani GC, Glasheen BM, Detor MM, Melkani A, Marsan NP, Swank DM, Bernstein SI. (2017) A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects. Dis Model Mech. Jun 1;10(6):761-771.

Barekat A, Gonzalez A, Mauntz RE, Kotzebue RW, Molina B, El-Mecharrafie N, Conner CJ, Garza S, Melkani GC, Joiner WJ, Lipinski MM, Finley KD, Ratliff EP (2016) Using Drosophila as an integrated model to study mild repetitive traumatic brain injury. Sci Rep. May 4;6:25252.

Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A1, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. (2016) A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila. J Mol Biol. 428(11):2446-61.

Shubhroz Gill, Hiep D. Le1, Girish C. Melkani, Satchidananda Panda. (2015) Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Science 13: Vol. 347 no. 6227 pp. 1265-1269.

Kronert WA, Melkani GC, Melkani A, Bernstein SI. (2015) Failure to Communicate MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTERDOMAIN INTERACTION. J Biol Chem. 290: 29270–29280.

Bloemink MJ, Melkani GC, Bernstein SI, Geeves MA. (2015) The relay-converter interface influences hydrolysis of ATP by skeletal muscle myosin II. J. Biol. Chem.. 291:1763-1773.

Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K, Melkani GC. (2014) Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis. Rare Dis. 2014 Nov 3;2(1).

Kronert WA, Melkani GC, Melkani A, Bernstein SI. (2014) Mapping interactions between myosin relay and converter domains that power muscle function. J Biol Chem. 289: 12779-90.

Lee CF, Melkani GC, Bernstein SI. (2014) The UNC-45 myosin chaperone: from worms to flies to vertebrates. Int Rev Cell Mol Biol. 313: 103-44.

Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. (2013) Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart. PLoS Genet. 10: e1004024

Kronert WA, Melkani GC, Melkani A, Bernstein SI. (2012) Alternative relay and converter domains tune native muscle myosin isoform function in Drosophila. J Mol Biol. 416:543-557.

Melkani GC, Sielaff R, Zardeneta G, Mendoza JA. (2012) Interaction of oxidized chaperonin GroEL with an unfolded protein at low temperatures.

Wang Y, Melkani GC, Suggs JA, Melkani A, Kronert WA, Cammarato A, Bernstein SI. (2012) Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness. Mol Biol Cell. 23:2057-65.

Caldwell JT, Melkani GC, Huxford T, Bernstein SI. (2011) Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system. Methods. 2012 56:25-32.

Bloemink M.J., Melkani G.C., Dambacher C.M., Bernstein S.I., Geeves M.A. (2011) Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities. J Biol Chem. 286: 28435-28443.

Melkani, G. C., R. Bodmer, K. Ocorr and S.I. Bernstein (2011) The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. PLoS One 6: e22579.

Lee, C. F., G. C. Melkani, Q. Yu, J. A. Suggs, W. A. Kronert, Y. Suzuki, L. Hipolito, M. G. Price, H. F. Epstein and S. I. Bernstein (2011) Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles and is essential for muscle myosin stability. J. Cell Sci. 24: 699-705.

Kronert, W. A., G. C. Melkani, A. Melkani and S. I. Bernstein (2010) Mutating the converter-relay interface of Drosophila myosin perturbs ATPase activity, actin motility, myofibril stability and flight ability. J. Mol. Biol. 398: 625-632.

Melkani, G. C., C. F. Lee, A. Cammarato and S. I. Bernstein (2010) Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase. Biochem. Biophys. Res. Comm. 396: 317-322.

Bloemink M. J., C. M. Dambacher, A. F. Knowles , G. C. Melkani, M. A. Geeves and S. I. Bernstein. (2009) Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head. J Mol Biol. 2009 389:707-721.

Melkani GC, Sielaff RL, Zardeneta G, Mendoza JA. (2008) Divalent cations stabilize GroEL under conditions of oxidative stress. Biochem Biophys Res Commun. Apr 11;368(3):625-30.

Melkani, G. C., A. Cammarato and S. I. Bernstein (2006) alphaB-Crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress. J. Mol. Biol. 358: 635-645.

Melkani GC, Kestetter J, Sielaff R, Zardeneta G, Mendoza JA. (2006) Protection of GroEL by its methionine residues against oxidation by hydrogen peroxide. Biochem Biophys Res Commun. Aug 25;347(2):534-9

Melkani GC, Zardeneta G, Mendoza JA. (2005) On the chaperonin activity of GroEL at heat-shock temperature. Int J Biochem Cell Biol. Jul;37(7):1375-85.

Melkani GC, Zardeneta G, Mendoza JA. (2004) Oxidized GroEL can function as a chaperonin. Front Biosci. Jan 1;9:724-31.

Melkani GC, McNamara C, Zardeneta G, Mendoza JA. (2004) Hydrogen peroxide induces the dissociation of GroEL into monomers that can facilitate the reactivation of oxidatively inactivated rhodanese. Int J Biochem Cell Biol. Mar;36(3):505-18.

Melkani GC, Zardeneta G, Mendoza JA. (2003) The ATPase activity of GroEL is supported at high temperatures by divalent cations that stabilize its structure. Biometals. Sep;16(3):479-84.

Srivastava S, Srivastava S, Melkani GC, Singh S, Gupta VD, Vijai Prakash G. (2002) Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B. Indian J Biochem Biophys. Dec;39(6):410-8.

Melkani GC, Zardeneta G, Mendoza JA. (2002) GroEL interacts transiently with oxidatively inactivated rhodanese facilitating its reactivation. Biochem Biophys Res Commun. Jun 21;294(4):893-9.

Singh S, Dwivedi S, Melkani GC, Rani C, Gaur SP, Mandal SK, Mahua J. (1999) Lipoprotein(a) and coronary heart disease in Indian population. J Assoc Physicians India. Dec;47(12):1157-60.

Singh S, Melkani GC, Rani C, Gaur SP, Agrawal V, Agrawal CG. (1997) Oxidative stress and metabolic control in non-insulin dependent diabetes mellitus. Indian J Biochem Biophys. Dec;34(6):512-7.

Note: Entrez Medline entries for a particular Author name may correspond with multiple authors with the same initials. Also, the list is limited to entries stored in the Entrez Medline Database and may not accurately reflect the true number of publications. You may also read the abstracts to the publications from this inquire.

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